Fragmentation of colicins A and E1 by cell surface proteases.

@article{Brey1982FragmentationOC,
  title={Fragmentation of colicins A and E1 by cell surface proteases.},
  author={Robert N. Brey},
  journal={Journal of bacteriology},
  year={1982},
  volume={149 1},
  pages={306-15}
}
Interaction of either colicin A or E1 with the surface of Escherichia coli cells resulted in extensive cleavage of the colicins into many peptide fragments in the molecular weight range of 10,000 to 30,000 released into the supernatants of colicin-cell mixtures. The protease inhibitor P-aminobenzamidine inhibited the cleavage of colicin A and enhanced colicin killing activity, suggesting that proteolysis is not required for the killing action of colicin. Fragments derived from the supernatants… CONTINUE READING