Fragmentation of Protonated Tripeptides : The Proline Effect Revisited

  title={Fragmentation of Protonated Tripeptides : The Proline Effect Revisited},
  author={Rajdeep Grewal and Houssain El Aribi and Alex G. Harrison and K. W. Michael Siu and Alan C. Hopkinson}
The fragmentation of protonated tripeptides under metastable ion conditions and collision-induced conditions are reported. The majority of protonated tripeptides cleave at the C-terminal amide bond to form b 2 and y1 ions, with the relative amounts depending on the proton affinities of the amino acids derived from the C-terminal amino acid residue. Protonated tripeptides that have a proline residue at the C-terminal position fragment almost exclusively by cleavage of the amide bond adjacent to… CONTINUE READING


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