Fragmentation and site-specific quantification of core fucosylated glycoprotein by multiple reaction monitoring-mass spectrometry.

@article{Zhao2011FragmentationAS,
  title={Fragmentation and site-specific quantification of core fucosylated glycoprotein by multiple reaction monitoring-mass spectrometry.},
  author={Yan Zhao and Wei Jia and Jifeng Wang and Wantao Ying and Yangjun Zhang and Xiaohong Qian},
  journal={Analytical chemistry},
  year={2011},
  volume={83 22},
  pages={8802-9}
}
Glycosylation modifications of proteins have been attracting increasing attention due to their roles in the physiological and pathological processes of the cell. Core fucosylation (CF), one special type of glycan structure in glycoproteins, has been linked with tumorigenesis. The study of protein glycosylation has been hindered by the technical challenges caused by the microheterogeneity of glycan modifications. In commonly used methods, sugar chains on the peptide were released using… CONTINUE READING