Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

@inproceedings{Mohanty2017FragmentLS,
  title={Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1},
  author={Biswaranjan Mohanty and Kieran A. Rimmer and R{\'o}is{\'i}n M McMahon and Stephen J. Headey and Mansha Vazirani and Stephen R. Shouldice and Mathieu Coinçon and Stephanie V Tay and Craig J Morton and Jamie S. Simpson and Jennifer L. Martin and Martin J Scanlon},
  booktitle={PloS one},
  year={2017}
}
At a time when the antibiotic drug discovery pipeline has stalled, antibiotic resistance is accelerating with catastrophic implications for our ability to treat bacterial infections. Globally we face the prospect of a future when common infections can once again kill. Anti-virulence approaches that target the capacity of the bacterium to cause disease rather than the growth or survival of the bacterium itself offer a tantalizing prospect of novel antimicrobials. They may also reduce the… CONTINUE READING
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