Fragment library design, synthesis and expansion: nurturing a synthesis and training platform.

Abstract

The availability of suitable diverse fragment- and lead-oriented screening compounds is key for the identification of suitable chemical starting points for drug discovery programs. The physicochemical properties of molecules are crucial in determining the success of small molecules in clinical development, yet reports suggest that pharmaceutical and… (More)
DOI: 10.1016/j.drudis.2016.10.005

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