Fragment-based drug discovery using rational design.

  • Harren Jhoti
  • Published 2007 in Ernst Schering Foundation symposium proceedings
Fragment-based drug discovery (FBDD) is established as an alternative approach to high-throughput screening for generating novel small molecule drug candidates. In FBDD, relatively small libraries of low molecular weight compounds (or fragments) are screened using sensitive biophysical techniques to detect their binding to the target protein. A lower… CONTINUE READING