Fragment based discovery of a novel and selective PI3 kinase inhibitor.


We report the use of fragment screening and fragment based drug design to develop a PI3γ kinase fragment hit into a lead. Initial fragment hits were discovered by high concentration biochemical screening, followed by a round of virtual screening to identify additional ligand efficient fragments. These were developed into potent and ligand efficient lead… (More)
DOI: 10.1016/j.bmcl.2011.07.117


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@article{Hughes2011FragmentBD, title={Fragment based discovery of a novel and selective PI3 kinase inhibitor.}, author={Samantha Jane Hughes and David S Millan and Iain C. Kilty and Russell A. Lewthwaite and John P. Mathias and Mark A O'Reilly and Andrew D Pannifer and Anne M Phelan and Frank St{\"u}hmeier and Darren A Baldock and David G. Brown}, journal={Bioorganic & medicinal chemistry letters}, year={2011}, volume={21 21}, pages={6586-90} }