Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry

@inproceedings{Vu2018FragmentBasedSO,
  title={Fragment-Based Screening of a Natural Product Library
against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry},
  author={Hoan T Vu and Liliana Pedro and Tin Mak and Brendan T. McCormick and Jessica Rowley and Miaomiao Liu and Angela Di Capua and Billy Williams-Noonan and Ngoc Thi Bich Pham and Rebecca H. Pouwer and Bao Kha Nguyen and Katherine Thea Andrews and Tina S. Skinner-Adams and Jessica Kim and Wim G. J. Hol and Raymond Hui and Gregory J. Crowther and Wesley C. Van Voorhis and Ronald J. Quinn},
  booktitle={ACS infectious diseases},
  year={2018}
}
Natural products are well known for their biological relevance, high degree of three-dimensionality, and access to areas of largely unexplored chemical space. To shape our understanding of the interaction between natural products and protein targets in the postgenomic era, we have used native mass spectrometry to investigate 62 potential protein targets for malaria using a natural-product-based fragment library. We reveal here 96 low-molecular-weight natural products identified as binding… CONTINUE READING
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