Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry

@inproceedings{Vu2018FragmentBasedSO,
  title={Fragment-Based Screening of a Natural Product Library
against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry},
  author={Hoan Vu and L. Pedro and Tin Mak and B. McCormick and J. Rowley and M. Liu and A. Di Capua and Billy Williams-Noonan and N. Pham and Rebecca H. Pouwer and B. Nguyen and K. Andrews and T. Skinner-Adams and J. Kim and W. Hol and R. Hui and Gregory J. Crowther and W. V. Van Voorhis and R. Quinn},
  booktitle={ACS infectious diseases},
  year={2018}
}
  • Hoan Vu, L. Pedro, +16 authors R. Quinn
  • Published in ACS infectious diseases 2018
  • Chemistry, Medicine
  • Natural products are well known for their biological relevance, high degree of three-dimensionality, and access to areas of largely unexplored chemical space. To shape our understanding of the interaction between natural products and protein targets in the postgenomic era, we have used native mass spectrometry to investigate 62 potential protein targets for malaria using a natural-product-based fragment library. We reveal here 96 low-molecular-weight natural products identified as binding… CONTINUE READING
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