Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry

  title={Fragment-Based Screening of a Natural Product Library
against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry},
  author={Hoan Vu and L. Pedro and Tin Mak and B. McCormick and J. Rowley and M. Liu and A. Di Capua and Billy Williams-Noonan and N. Pham and Rebecca H. Pouwer and B. Nguyen and K. Andrews and T. Skinner-Adams and J. Kim and W. Hol and R. Hui and Gregory J. Crowther and W. V. Van Voorhis and R. Quinn},
  booktitle={ACS infectious diseases},
  • Hoan Vu, L. Pedro, +16 authors R. Quinn
  • Published in ACS infectious diseases 2018
  • Chemistry, Medicine
  • Natural products are well known for their biological relevance, high degree of three-dimensionality, and access to areas of largely unexplored chemical space. To shape our understanding of the interaction between natural products and protein targets in the postgenomic era, we have used native mass spectrometry to investigate 62 potential protein targets for malaria using a natural-product-based fragment library. We reveal here 96 low-molecular-weight natural products identified as binding… CONTINUE READING
    22 Citations

    Figures, Tables, and Topics from this paper.

    Fragment-based screening with natural products for novel anti-parasitic disease drug discovery
    • M. Liu, R. Quinn
    • Chemistry, Medicine
    • Expert opinion on drug discovery
    • 2019
    • 3
    Plant natural fragments, an innovative approach for drug discovery
    • 1
    Cheminformatic Analysis of Natural Product Fragments.
    • D. Reker
    • Computer Science, Medicine
    • Progress in the chemistry of organic natural products
    • 2019
    Re-engineering natural products to engage new biological targets.
    Fragment-based drug design of nature-inspired compounds
    • 1
    • Highly Influenced
    Creating and screening natural product libraries.
    • 4
    • PDF
    Principle and design of pseudo-natural products
    • 12
    • PDF


    Natural-product-derived fragments for fragment-based ligand discovery
    • 172
    Mass spectrometry for fragment screening.
    • 11
    The rise of fragment-based drug discovery.
    • 422
    In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
    • 369
    • PDF
    Increasing the Coverage of Medicinal Chemistry-Relevant Space in Commercial Fragments Screening
    • 15
    • PDF