Fragment-Based Screening by Protein Crystallography: Successes and Pitfalls

Abstract

Fragment-based drug discovery (FBDD) concerns the screening of low-molecular weight compounds against macromolecular targets of clinical relevance. These compounds act as starting points for the development of drugs. FBDD has evolved and grown in popularity over the past 15 years. In this paper, the rationale and technology behind the use of X-ray… (More)
DOI: 10.3390/ijms131012857

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Cite this paper

@inproceedings{Chilingaryan2012FragmentBasedSB, title={Fragment-Based Screening by Protein Crystallography: Successes and Pitfalls}, author={Zorik Chilingaryan and Zhou Yin and Aaron J. Oakley}, booktitle={International journal of molecular sciences}, year={2012} }