Fragile sites are targets of diverse mutagens and carcinogens.

  title={Fragile sites are targets of diverse mutagens and carcinogens.},
  author={J{\"o}rge J. Yunis and A L Soreng and Ann E. Bowe},
  volume={1 1},
Using a high-resolution chromosome banding technique with cultured human lymphocytes and caffeine as a mutagen enhancer, 16 different mutagens and carcinogens were found to induce 110 recurrent fragile sites. All agents produced chromosome breaks and the majority of the 110 recurrent break sites involved were elicited by at least half of all agents, even though they act through different molecular mechanisms. Two of the agents used are known to induce hypersensitive chromatin sites in… CONTINUE READING

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