Fragile sites, Alzheimer's disease, and aging.

  title={Fragile sites, Alzheimer's disease, and aging.},
  author={M H Kormann-Bortolotto and Marilia Cardoso Smith and J T Toniolo Neto},
  journal={Mechanisms of ageing and development},
  volume={65 1},
The fragile site expression under conditions of folate deprivation was compared in the chromosomes from 5 Alzheimer's disease (AD) female patients, 5 healthy elderly females and 5 healthy young females. Although different fragile sites were observed in the three groups, nevertheless, more similarities were found between the AD patients and elderly normal donors. The only fragile site common to all groups was 3p14. This site was the most frequent in the young donors group. In both AD and elderly… CONTINUE READING