Fragile histidine triad-mediated tumor suppression of lung cancer by targeting multiple components of the Ras/Rho GTPase molecular switch.

@article{Jayachandran2007FragileHT,
  title={Fragile histidine triad-mediated tumor suppression of lung cancer by targeting multiple components of the Ras/Rho GTPase molecular switch.},
  author={Gitanjali Jayachandran and Ji-ichiro Sazaki and Masahito Nishizaki and Kai Xu and Luc Girard and John D. Minna and J. L. A. Roth and Lin Qin Ji},
  journal={Cancer research},
  year={2007},
  volume={67 21},
  pages={10379-88}
}
The fragile histidine triad (FHIT) gene has been shown to function as a tumor suppressor gene in vitro and in vivo. However, the mechanism of its action is still largely unknown. To elucidate the molecular mechanism and biological pathway in FHIT-mediated tumor suppression, we used a complementary gene and protein expression profiling with DNA microarray and ProteinChip technologies to quantitatively monitor cellular changes in gene and protein expression and discover the molecular targets of… CONTINUE READING
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