Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study--preliminary data.

Abstract

The preliminary results of an international collaborative study examining premature menopause in fragile X carriers are presented. A total of 760 women from fragile X families was surveyed about their fragile X carrier status and their menstrual and reproductive histories. Among the subjects, 395 carried a premutation, 128 carried a full mutation, and 237 were noncarriers. Sixty-three (16%) of the premutation carriers had experienced menopause prior to the age of 40 compared with none of the full mutation carriers and one (0.4%) of the controls. Based on these preliminary data, there is a significant association between fragile X premutation carrier status and premature menopause.

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@article{AllinghamHawkins1999FragileXP, title={Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study--preliminary data.}, author={Diane J Allingham-Hawkins and Riyana Babul-Hirji and David A. Chitayat and Jeanette J A Holden and Kevin T Yang and Charles Tzu-Chi Lee and Richard A. Hudson and H Gorwill and Sarah L. Nolin and Alison Glicksman and Edmund C Jenkins and William Brown and Patricia N. Howard-Peebles and Carlo Maria Becchi and Elizabeth Cummings and Lee A Fallon and Stella Seitz and Susan H. Black and Angela Maria Vianna-Morgante and Sofia Santos Costa and Paulo Alberto Otto and Regina C{\'e}lia Mingroni-Netto and A . Murray and Jocasta A Webb and F Vieri}, journal={American journal of medical genetics}, year={1999}, volume={83 4}, pages={322-5} }