Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila

@inproceedings{Friedman2013FragileXM,
  title={Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila},
  author={Samuel Friedman and Neil Dani and Emma Rushton and Kendal Broadie},
  booktitle={Disease models & mechanisms},
  year={2013}
}
Fragile X syndrome (FXS), the most common inherited determinant of intellectual disability and autism spectrum disorders, is caused by loss of the fragile X mental retardation 1 (FMR1) gene product (FMRP), an mRNA-binding translational repressor. A number of conserved FMRP targets have been identified in the well-characterized Drosophila FXS disease model, but FMRP is highly pleiotropic in function and the full spectrum of FMRP targets has yet to be revealed. In this study, screens for… CONTINUE READING
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