Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation.

@article{Weiler1997FragileXM,
  title={Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation.},
  author={Ivan Jeanne Weiler and Scott A Irwin and Anna Y. Klintsova and Corinne M. Spencer and A D Brazelton and Kevin Y. Miyashiro and Thomas A. Comery and Bipin D. Patel and James Eberwine and William T. Greenough},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 10},
  pages={5395-400}
}
Local translation of proteins in distal dendrites is thought to support synaptic structural plasticity. We have previously shown that metabotropic glutamate receptor (mGluR1) stimulation initiates a phosphorylation cascade, triggering rapid association of some mRNAs with translation machinery near synapses, and leading to protein synthesis. To determine the identity of these mRNAs, a cDNA library produced from distal nerve processes was used to screen synaptic polyribosome-associated mRNA. We… CONTINUE READING
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