Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density

@inproceedings{Ferron2014FragileXM,
  title={Fragile X mental retardation protein
controls synaptic vesicle exocytosis by modulating N-type calcium channel density},
  author={Laurent Ferron and Manuela Nieto-Rostro and John S. Cassidy and Annette C Dolphin},
  booktitle={Nature communications},
  year={2014}
}
Fragile X syndrome (FXS), the most common heritable form of mental retardation, is characterized by synaptic dysfunction. Synaptic transmission depends critically on presynaptic calcium entry via voltage-gated calcium (Ca(V)) channels. Here we show that the functional expression of neuronal N-type Ca(V) channels (Ca(V)2.2) is regulated by fragile X mental retardation protein (FMRP). We find that FMRP knockdown in dorsal root ganglion neurons increases Ca(V) channel density in somata and in… CONTINUE READING

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