Fragile X Mental Retardation Protein Regulates Synaptic and Behavioral Plasticity to Repeated Cocaine Administration

@article{Smith2014FragileXM,
  title={Fragile X Mental Retardation Protein Regulates Synaptic and Behavioral Plasticity to Repeated Cocaine Administration},
  author={Laura N. Smith and Jakub P. Jedynak and Miles R. Fontenot and Carly F. Hale and Karen C. Dietz and Makoto Taniguchi and F. Scarlett Thomas and Benjamin C. Zirlin and Shari G Birnbaum and Kimberly M Huber and M. J. -Andr{\'e} Thomas and Christopher W Cowan},
  journal={Neuron},
  year={2014},
  volume={82},
  pages={645-658}
}
Repeated cocaine exposure causes persistent, maladaptive alterations in brain and behavior, and hope for effective therapeutics lies in understanding these processes. We describe here an essential role for fragile X mental retardation protein (FMRP), an RNA-binding protein and regulator of dendritic protein synthesis, in cocaine conditioned place preference, behavioral sensitization, and motor stereotypy. Cocaine reward deficits in FMRP-deficient mice stem from elevated mGluR5 (or GRM5… CONTINUE READING
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