Fragile X: Translation in Action

@article{Bear2008FragileXT,
  title={Fragile X: Translation in Action},
  author={Mark F. Bear and G{\"u}l D{\"o}len and Emily K Osterweil and Naveen Nagarajan},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={84-87}
}
Fragile X is a synapsopathy—a disorder of synaptic function and plasticity. Recent studies using mouse models of the disease suggest that the critical defect is altered regulation of synaptic protein synthesis. Various strategies to restore balanced synaptic protein synthesis have been remarkably successful in correcting widely varied mutant phenotypes in mice. Insights gained by the study of synaptic plasticity in animal models of fragile X have suggested novel therapeutic approaches, not only… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

Targeted treatments for fragile X syndrome

Journal of Neurodevelopmental Disorders • 2011
View 7 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 28 references

The autistic neuron

RJ Kelleher, MF Bear
Cell (in press). • 2007
View 1 Excerpt

Genetic interaction between Fmr1 and Grm5: a role for mGluR5 in the pathogenesis of fragile X syndrome

G Dolen, E Osterweil, MF Bear
Neuroscience Abstracts 33: 196.193. • 2006
View 1 Excerpt

Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2006
View 1 Excerpt

Dendritic spine abnormalities in the occipital cortex of C57BL/6 Fmr1 knockout mice.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2005
View 1 Excerpt

Postadolescent changes in regional cerebral protein synthesis: an in vivo study in the FMR1 null mouse.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
View 1 Excerpt

Similar Papers

Loading similar papers…