Fragile X: Translation in Action

  title={Fragile X: Translation in Action},
  author={Mark F. Bear and G{\"u}l D{\"o}len and Emily K Osterweil and Naveen Nagarajan},
Fragile X is a synapsopathy—a disorder of synaptic function and plasticity. Recent studies using mouse models of the disease suggest that the critical defect is altered regulation of synaptic protein synthesis. Various strategies to restore balanced synaptic protein synthesis have been remarkably successful in correcting widely varied mutant phenotypes in mice. Insights gained by the study of synaptic plasticity in animal models of fragile X have suggested novel therapeutic approaches, not only… CONTINUE READING

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