Fractured genes: a novel genomic arrangement involving new split inteins and a new homing endonuclease family

@inproceedings{Dassa2009FracturedGA,
  title={Fractured genes: a novel genomic arrangement involving new split inteins and a new homing endonuclease family},
  author={Bareket Dassa and N. London and Barry L. Stoddard and Ora Schueler-Furman and Shmuel Pietrokovski},
  booktitle={Nucleic acids research},
  year={2009}
}
Inteins are genetic elements, inserted in-frame into protein-coding genes, whose products catalyze their removal from the protein precursor via a protein-splicing reaction. Intein domains can be split into two fragments and still ligate their flanks by a trans-protein-splicing reaction. A bioinformatic analysis of environmental metagenomic data revealed 26 different loci with a novel genomic arrangement. In each locus, a conserved enzyme coding region is broken in two by a split intein, with a… CONTINUE READING

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