Fracture prevalence and relationship to endocrinopathy in iron overloaded patients with sickle cell disease and thalassemia.

@article{Fung2008FracturePA,
  title={Fracture prevalence and relationship to endocrinopathy in iron overloaded patients with sickle cell disease and thalassemia.},
  author={Ellen B. Fung and Paul R. Harmatz and Meredith J Milet and Thomas D. Coates and Alexis A Thompson and Mark A. Ranalli and Robert Mignaca and Charles Scher and Patricia J. V. Giardina and Shanda Robertson and Lynne D Neumayr and Elliott Vichinsky},
  journal={Bone},
  year={2008},
  volume={43 1},
  pages={162-168}
}
Transfusional iron overload leads to gonadal failure and low bone mass in patients with thalassemia (Thal). However, gonadal failure is rarely reported in transfused patients with sickle cell disease (SCD) and the literature regarding fracture prevalence in SCD is limited. The objective of this study was to assess self-reported fracture prevalence and its relationship to endocrinopathy in transfused Thal or SCD subjects and compare to non-transfused subjects with SCD (NonTxSCD). Eligibility was… CONTINUE READING

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