Fracture induced mobilization and incorporation of bone marrow-derived endothelial progenitor cells for bone healing.

@article{Matsumoto2008FractureIM,
  title={Fracture induced mobilization and incorporation of bone marrow-derived endothelial progenitor cells for bone healing.},
  author={Tomoyuki Matsumoto and Yutaka Mifune and Atsuhiko Kawamoto and Ryosuke Kuroda and Taro Shoji and Hiroto Iwasaki and Takahiro Suzuki and Akira Oyamada and Miki Horii and Ayumi Yokoyama and Hiromi Nishimura and Sang Yang Lee and Masahiko Miwa and Minoru Doita and Masahiro Kurosaka and Takayuki Asahara},
  journal={Journal of cellular physiology},
  year={2008},
  volume={215 1},
  pages={234-42}
}
We recently reported that systemic administration of peripheral blood (PB) CD34+ cells, an endothelial progenitor cell (EPC)-enriched population, contributed to fracture healing via vasculogenesis/angiogenesis. However, pathophysiological role of EPCs in fracture healing process has not been fully clarified. Therefore, we investigated the hypothesis whether mobilization and incorporation of bone marrow (BM)-derived EPCs may play a pivotal role in appropriate fracture healing. Serial… CONTINUE READING