Fracture Prevention with Zoledronate in Older Women with Osteopenia.

  title={Fracture Prevention with Zoledronate in Older Women with Osteopenia.},
  author={Ian R Reid and Anne M. Horne and Borislav Mihov and Angela Stewart and E. Carlton Garratt and Sumwai Wong and Katy R. Wiessing and Mark J Bolland and Sonja T Bastin and Gregory David Gamble},
  journal={The New England journal of medicine},
  volume={379 25},
BACKGROUND Bisphosphonates prevent fractures in patients with osteoporosis, but their efficacy in women with osteopenia is unknown. Most fractures in postmenopausal women occur in those with osteopenia, so therapies that are effective in women with osteopenia are needed. METHODS We conducted a 6-year, double-blind trial involving 2000 women with osteopenia (defined by a T score of -1.0 to -2.5 at either the total hip or the femoral neck on either side) who were 65 years of age or older… CONTINUE READING


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