Fracture Incidence in Polyostotic Fibrous Dysplasia and the McCune‐Albright Syndrome

@article{Leet2004FractureII,
  title={Fracture Incidence in Polyostotic Fibrous Dysplasia and the McCune‐Albright Syndrome},
  author={Arabella I. Leet and Caroline M. Chebli and Harvey W Kushner and Clara C. Chen and Marilyn H. Kelly and Beth A. Brillante and Pamela Gehron Robey and Paolo Bianco and Shlomo Wientroub and Michael T Collins},
  journal={Journal of Bone and Mineral Research},
  year={2004},
  volume={19}
}
In patients with polyostotic fibrous dysplasia of bone, the peak incidence of fractures is during the first decade of life, followed by a decrease thereafter. Phosphaturia is associated with an earlier incidence and increased frequency of fractures. 
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132 Citations
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132 Citations

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In open studies, bisphosphonate therapy (pamidronate, alendronate) reduced bone pain associated with fibrous dysplasia of bone and was associated to some radiological improvement. Calcium, vitamin D,…
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The authors report the case of a 31-year-old man with polyostotic fibrous dysplasia who suffered a traumatic odontoid fracture in an area of a preexisting bone lesion. Conservative treatment was…
Onset, Progression, and Plateau of Skeletal Lesions in Fibrous Dysplasia and the Relationship to Functional Outcome
  • Elizabeth S Hart, M. Kelly, M. Collins
  • Medicine, Psychology
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2007
Most lesions in FD and their attendant functional disability occur within the first decade; 90% of lesions are present by 15 years, and the median age when assistive devices are needed is 7 years.…
Percutaneous kyphoplasty for vertebral fracture second to polyostotic fibrous dysplasia : a case report and review of the literature
TLDR
Percutaneous kyphoplasty may be a usable choice to treat the patients with vertebral fracture second to polyostotic fibrous dysplasia in McCune-Albright syndrome.
Pseudarthrosis in fibrous dysplasia treated with bone morphogenetic protein
TLDR
A patient suffering from polyostotic fibrous dysplasia of the right part of the body that was successfully treated with bone morphogenetic protein-7/osteogenic protein-1 is presented.
Fibrous Dysplasia of Bone and McCune–Albright Syndrome: A Bench to Bedside Review
TLDR
This review summarizes the current understanding of pathophysiology in fibrous dysplasia, describes key pre-clinical and clinical investigations, and details the current approach to diagnosis and management.
A case of fracture in fibrous dysplasia of the mandible
TLDR
A case of mandibular fracture in fibrous dysplasia arising in a 19-year-old man with suspected Gsα somatic mutation leading to abnormal development of the osteogenic mesenchymal tissue is reported.
McCune-Albright syndrome: Report of a case
TLDR
Considering the presence of polyostotic fibrous dysplasia, precocious puberty and cafe au lait macular spots, MacCune-Albright syndrome was confirmed in this patient.
Congenital and metabolic disorders leading to fracture
TLDR
A review of congenital and metabolic causes of fractures is presented, focusing largely on the details of osteogenesis imperfecta and congenital pseudoarthrosis of the tibia.
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