Fractions metabolized in a triangular metabolic system: Cinromide and two metabolites in the rhesus monkey

@article{Lane2005FractionsMI,
  title={Fractions metabolized in a triangular metabolic system: Cinromide and two metabolites in the rhesus monkey},
  author={E. Lane and R. Levy},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={2005},
  volume={13},
  pages={373-386}
}
  • E. Lane, R. Levy
  • Published 2005
  • Biology, Medicine
  • Journal of Pharmacokinetics and Biopharmaceutics
A previous study of the metabolic fate of cinromide (3-bromo-N-ethylcinnamamide) in rhesus monkey established that half of a dose is metabolized byN-deethylation to an active metabolite, 3-bromocinnamamide. Both cinromide and its proximal metabolite can be metabolized by amide hydrolysis to a second metabolite, 3-bromocinnamic acid, resulting in a triangular metabolic problem. This investigation was undertaken to distinguish between these two nonexclusive possibilites. A preliminary study was… Expand
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