Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus.

@article{Pogribny2005FractionatedLR,
  title={Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus.},
  author={Igor P Pogribny and Igor Koturbash and Volodymyr P. Tryndyak and Darryl Hudson and Sandie M L Stevenson and Olga A. Sedelnikova and W. M. Bonner and Olga Kovalchuk},
  journal={Molecular cancer research : MCR},
  year={2005},
  volume={3 10},
  pages={553-61}
}
Thymus, an important component of hematopoietic tissue, is a well-documented "target" of radiation carcinogenesis. Both acute and fractionated irradiation result in a high risk of leukemia and thymic lymphoma. However, the exact mechanisms underlying radiation-induced predisposition to leukemia and lymphoma are still unknown, and the contributions of genetic and epigenetic mechanisms in particular have yet to be defined. Global DNA hypomethylation is a well-known characteristic of cancer cells… CONTINUE READING

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