Fractionated infusions of cryopreserved stem cells may prevent DMSO-induced major cardiac complications in graft recipients.

@article{Martino1996FractionatedIO,
  title={Fractionated infusions of cryopreserved stem cells may prevent DMSO-induced major cardiac complications in graft recipients.},
  author={Massimo Martino and Fortunato Morabito and Giuseppe Messina and Giuseppe Irrera and Giulia Pucci and Pasquale Iacopino},
  journal={Haematologica},
  year={1996},
  volume={81 1},
  pages={
          59-61
        }
}
The amount of transfused dimethyl sulfoxide (DMSO) is indicated as the major cause of the cryoprotectant-related toxicity in autologous stem cell recipients, with a high incidence of major cardiac side effects. In this study we tried to discover whether fractionated infusion of the total graft volume could prevent the DMSO-related major cardiovascular side effects. We conclude that continuous cardiac monitoring during and after fractionated infusions of DMSO-containing graft documented no major… CONTINUE READING
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Treatment of normal donors with rhG-CSF 16 μg/kg for mobilization of peripheral blood stem cells (PBSC) and their apheretic collection in view of allogeneic transplantation

  • I Majolino, F Buscemi, R Scimé
  • Haematologica
  • 1995

Cardiac arrest after autologous peripheral blood stem cells

  • AP Rapoport, JM Rowe, CH Packman, SJ. Ginsberg
  • Bone Marrow Transplant
  • 1991

Preservation of hemopoietic stemcells. Transplantation potential and CFU-C activity of frozen marrow tested in mice, monkeys and man

  • VW Schaefer, KA Dicke
  • Cryopreservation of normal and neoplastic cells…
  • 1973
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