Fractionated abdominal irradiation induces intestinal microvascular changes in an in vivo model of radiotherapy-induced gut toxicity

@article{Stansborough2017FractionatedAI,
  title={Fractionated abdominal irradiation induces intestinal microvascular changes in an in vivo model of radiotherapy-induced gut toxicity},
  author={Romany L Stansborough and Emma H. Bateman and Noor Al-Dasooqi and Joanne M Bowen and Dorothy M. K. Keefe and Ann S. J. Yeoh and Richard Logan and Eric E. K. Yeoh and A. D. Draper. J. M. Spiers Stringer and Rachel J. Gibson},
  journal={Supportive Care in Cancer},
  year={2017},
  volume={25},
  pages={1973-1983}
}
Radiotherapy-induced gut toxicity (RIGT) is associated with diarrhoea, pain and rectal bleeding and can occur as an acute or chronic toxicity. The microvasculature has been shown to be altered in the development of RIGT; however, the features are not yet characterized. We hypothesized that apoptosis of microvascular cells would occur early in the gastrointestinal tract following fractionated irradiation, followed by late microvascular changes, including sclerosis and telangiectasis. Female Dark… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Similar Papers

Loading similar papers…