Fractionated Illumination for Oesophageal ALA-PDT: Effect on Blood Flow and PpIX Formation

@article{Boogert2001FractionatedIF,
  title={Fractionated Illumination for Oesophageal ALA-PDT: Effect on Blood Flow and PpIX Formation},
  author={Jolanda van den Boogert and Hugo J. van Staveren and R.W.F. de Bruin and Peter D Siersema and Richard van Hillegersberg},
  journal={Lasers in Medical Science},
  year={2001},
  volume={16},
  pages={16-25}
}
Abstract. The effect of fractionating the 633 nm illumination of 5-aminolaevulinic (ALA)-based photodynamic therapy (PDT) of the normal rat oesophagus was studied. Fractionation of the illumination could enhance the PDT effect in two ways: (a) delay of the vascular shutdown or relaxation of the vasoconstriction induced by ALA-PDT and (b) use of newly formed protoporphyrin IX (PpIX), produced during the dark interval. Forty rats were randomly allocated to two groups of 20 animals each. To study… CONTINUE READING

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