Fractionated Feridex and positive contrast: in vivo MR imaging of atherosclerosis.

  title={Fractionated Feridex and positive contrast: in vivo MR imaging of atherosclerosis.},
  author={Karen C. Briley-Saebo and Venkatesh Mani and Fabien Hyafil and J. -C. Cornily and Zahi A. Fayad},
  journal={Magnetic resonance in medicine},
  volume={59 4},
Macrophages have been identified as a critical factor in the pathogenesis of atherosclerosis. Ultrasmall iron oxide particles (USPIOs) have been used to passively target intraplaque macrophages. For dextran-based USPIOs, uptake into macrophages may be modulated by particle size. The aim of the current study was to test the efficacy of fractionated Feridex with respect to macrophage uptake in atherosclerotic rabbits. Fractionation of Feridex resulted in a 15-nm USPIO that exhibited a blood half… CONTINUE READING
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