Fractional maximal effect method for in vitro synergy between amoxicillin and ceftriaxone and between vancomycin and ceftriaxone against Enterococcus faecalis and penicillin-resistant Streptococcus pneumoniae.

@article{Desbiolles2001FractionalME,
  title={Fractional maximal effect method for in vitro synergy between amoxicillin and ceftriaxone and between vancomycin and ceftriaxone against Enterococcus faecalis and penicillin-resistant Streptococcus pneumoniae.},
  author={Norbert Desbiolles and Lionel Piroth and Catherine Lequeu and Catherine Neuwirth and Henri Portier and Pascal Chavanet},
  journal={Antimicrobial agents and chemotherapy},
  year={2001},
  volume={45 12},
  pages={3328-33}
}
In the present study we assessed the use of a new in vitro testing method and graphical representation of the results to investigate the potential effectiveness of combinations of amoxicillin (AMZ) plus ceftriaxone (CRO) and of CRO plus vancomycin (VAN) against strains of Streptococcus pneumoniae highly resistant to penicillin and cephalosporins (PRP strains). We used the fractional maximal effect (FME) method of time-kill curves to calculate adequate concentrations of the drugs to be tested… CONTINUE READING

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