Fractalkine shares signal sequence with TARC: gene structures and expression profiles of two chemokine genes.

@article{Hiroyama2001FractalkineSS,
  title={Fractalkine shares signal sequence with TARC: gene structures and expression profiles of two chemokine genes.},
  author={Takashi Hiroyama and Atsushi Iwama and Yuka Nakamura and Hiromitsu Nakauchi},
  journal={Genomics},
  year={2001},
  volume={75 1-3},
  pages={3-5}
}
In the process of cloning the gene (Scyd1) encoding the mouse CX3C chemokine fractalkine, we identified a novel cDNA that encodes a chimeric molecule termed fracTARC. This molecule is a variant form of the mouse CC chemokine, TARC (for thymus- and activation-regulated chemokine), bearing the fractalkine signal sequence instead of its own. Analysis of the genomic organization of the two genes revealed that Scyd1 and Scya17, encoding TARC, are tightly linked on chromosome 8 and that fracTARC is… CONTINUE READING