Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation under Physiologic Flow

@article{Fong1998FractalkineAC,
  title={Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation  under Physiologic Flow },
  author={Alan M. Fong and Lisa Annette Robinson and Douglas A. Steeber and Thomas F. Tedder and Osamu Yoshie and Toshio Imai and Dhavalkumar D. Patel},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={188},
  pages={1413 - 1419}
}
Leukocyte migration into sites of inflammation involves multiple molecular interactions between leukocytes and vascular endothelial cells, mediating sequential leukocyte capture, rolling, and firm adhesion. In this study, we tested the role of molecular interactions between fractalkine (FKN), a transmembrane mucin-chemokine hybrid molecule expressed on activated endothelium, and its receptor (CX3CR1) in leukocyte capture, firm adhesion, and activation under physiologic flow conditions… CONTINUE READING
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