Fractalkine: a novel angiogenic chemokine in rheumatoid arthritis.

  title={Fractalkine: a novel angiogenic chemokine in rheumatoid arthritis.},
  author={M V Volin and James M. Woods and Mohammad A. Amin and Matthew A. Connors and Lisa A. Harlow and Alisa Erika Koch},
  journal={The American journal of pathology},
  volume={159 4},
Angiogenesis is an important aspect of the vasculoproliferation found in the rheumatoid arthritic (RA) pannus. We have previously implicated members of the CXC chemokine family as potent angiogenic mediators in RA. We investigated the possibility that the sole member of the CX(3)C chemokine family, fractalkine (fkn), induces angiogenesis and that fkn might mediate angiogenesis in RA. Recombinant human fkn significantly induced migration of human dermal microvascular endothelial cells (HMVECs… CONTINUE READING