Fractal dimension can distinguish models and pharmacologic changes in liver fibrosis in rats.

@article{Moal2002FractalDC,
  title={Fractal dimension can distinguish models and pharmacologic changes in liver fibrosis in rats.},
  author={Fr{\'e}d{\'e}ric Moal and Daniel Chappard and Jianhua Wang and Eric Vuillemin and Sophie Michalak-Provost and Marie Christine Rousselet and Fr{\'e}d{\'e}ric Oberti and Paul Cal{\`e}s},
  journal={Hepatology},
  year={2002},
  volume={36 4 Pt 1},
  pages={840-9}
}
Fractal analysis measures the complexity of geometric structures. The aim of this study was to evaluate the feasibility and accuracy of fractal analysis in liver fibrosis. A total of 77 rats were included: 10 sham, 46 with fibrosis secondary to bile duct ligation (BDL), and 21 with fibrosis due to CCl(4) intoxication. Measurements included the fractal dimension of Kolmogorov (D(k)), histologic lesions, the area of fibrosis by image analysis, liver hydroxyproline content, messenger RNA… CONTINUE READING

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