Frabin, a Novel FGD1-related Actin Filament-binding Protein Capable of Changing Cell Shape and Activating c-Jun N-terminal Kinase*

@article{Obaishi1998FrabinAN,
  title={Frabin, a Novel FGD1-related Actin Filament-binding Protein Capable of Changing Cell Shape and Activating c-Jun N-terminal Kinase*},
  author={Hiroshi Obaishi and Hiroyuki Nakanishi and Kenji Mandai and Keiko Satoh and Ayako Satoh and Kazuhiko Takahashi and Masako Miyahara and Hideo Nishioka and Kenji Takaishi and Yoshimi Takai},
  journal={The Journal of Biological Chemistry},
  year={1998},
  volume={273},
  pages={18697 - 18700}
}
We purified from rat brain a novel F-actin-binding protein with a M r of about 105,000 (p105), which was estimated by SDS-polyacrylamide gel electrophoresis. We cloned its cDNA from a rat brain cDNA library and characterized it. p105 was a protein of 766 amino acids and showed a calculated M r of 86,449. p105 consisted of one F-actin-binding domain at the N-terminal region, one Dbl homology domain and one pleckstrin homology domain at the middle region, and one cysteine-rich domain at the C… Expand
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