Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages

  title={Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages},
  author={Qingshan Wang and Hong Ni and Lan Lan and Xiaoli Wei and Rong Xiang and Yue Wang},
  journal={Cell Research},
The tumor microenvironment (TME) plays a prominent role in the growth of tumor cells. As the major inflammatory component of the TME, M2d macrophages are educated by the TME such that they adopt an immunosuppressive role that promotes tumor metastasis and progression. Fra-1 forms activator protein-1 heterodimers with Jun partners and drives gene transcription. Fra-1 is thought to drastically induce tumorigenesis and progression. However, the functional role of Fra-1 in the generation of M2d… 

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