Fra-1 potentiates osteoclastic differentiation in osteoclast-macrophage precursor cell lines.

@article{Owens1999Fra1PO,
  title={Fra-1 potentiates osteoclastic differentiation in osteoclast-macrophage precursor cell lines.},
  author={Jane M. Owens and Ken-ichiro Matsuo and Geoffrey Charles Nicholson and Erwin F Wagner and Timothy John Chambers},
  journal={Journal of cellular physiology},
  year={1999},
  volume={179 2},
  pages={170-8}
}
c-Fos, a component of the dimeric transcription factor AP-1, is necessary for osteoclast formation. To determine whether c-Fos can substitute for any or all of the stimuli needed for osteoclast induction, we infected osteoclast precursors with retroviral vectors expressing c-Fos or the Fos-related protein, Fra-1. The infected cells were incubated with or without osteoclast-inductive stimuli. Osteoclast formation from retroviral-infected precursors remained completely dependent on osteoclast… CONTINUE READING

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