Frégoli syndrome associated with levodopa treatment
@article{Stewart2008FrgoliSA, title={Fr{\'e}goli syndrome associated with levodopa treatment}, author={Jonathan T. Stewart}, journal={Movement Disorders}, year={2008}, volume={23} }
Acknowledgments: The authors thank the patient and her mother for their commitment to furthering our understanding of this condition and other disorders affecting the cerebellum. We also thank Richard Johnson, MD for his contribution to the care of this patient. This work was supported in part by the Doris Duke Charitable Foundation and Harvard Medical School (RCG) and the Birmingham Foundation (JDS).
12 Citations
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- Psychology, MedicineThe Journal of neuropsychiatry and clinical neurosciences
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A patient with advanced PD and combined Capgras and intermetamorphosis syndromes for whom known predisposing factors appear to be insufficient to explain DMS in PD is described.
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Two cases of Parkinson’s disease with an unusual delusional misidentification, intermetamorphosis, are presented, along with their improvement with pimavanserin, a novel atypical antipsychotic medication.
Behavioral effects of levodopa
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Appropriate management remains challenging, because reduction of levodopa (l‐dopa) and dopaminergic treatment is often recommended; however, doses required for control of motor symptoms may still induce behavioral changes.
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The initial management approach should focus on identification and treatment of any contributory medical factors, reduction or discontinuation of medications with potential to induce or worsen psychosis, nonpharmacological strategies and consideration of acetylcholinesterase inhibitor treatment in the setting of dementia.
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Behçet’s Syndrome (BS) is a multi-system, vascular-inflammatory disease of unknown origin, involving the nervous system in a subgroup of patients. The growing clinical and imaging evidence suggests…
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Effective and well-studied treatments that improve Parkinson’s disease psychosis without worsening motor function are still needed.
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An evidence-based review on the etiology, prevalence and management of psychotic symptoms in Parkinson?s disease is provided and a complex interrelationship of factors associated with the disease itself and the factors associated with antiparkinsonian medications is suggested.
An update expert opinion on management and research strategies in Parkinson's disease psychosis
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Novel research strategies focus on nondopaminergic systems and incorporate neuroimaging, genetic associations and animal models and have the potential to enhance understanding of PD psychosis and advance the development of agents that can ultimately be tested in well-designed, randomized, controlled trials.
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