Foxp3 positive regulatory T cells: a functional regulation by the E3 ubiquitin ligase Itch

Abstract

Regulatory T cells (Tregs) play a critical role in maintaining immune tolerance to self-antigens, whose development and activation is controlled by the master regulator and transcription factor Foxp3. Foxp3 acts as transcription repressor and exerts its suppressing function via directly associating with and inhibiting the function of other transcriptional… (More)
DOI: 10.1007/s00281-009-0192-1

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Cite this paper

@article{Su2009Foxp3PR, title={Foxp3 positive regulatory T cells: a functional regulation by the E3 ubiquitin ligase Itch}, author={Jin Su and Yun-cai Liu}, journal={Seminars in Immunopathology}, year={2009}, volume={32}, pages={149-156} }