Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth

  title={Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth},
  author={Soraya Zorro Manrique and Maria Adelaida Duque Correa and Dominique B. Hoelzinger and Ana Lucia Dominguez and Noweeda Mirza and H Lin and Joan Stein-Streilein and Siamon Gordon and Joseph Lustgarten},
  booktitle={The Journal of experimental medicine},
Regulatory T cells (T reg cells) are characterized by the expression of the forkhead lineage-specific transcription factor Foxp3, and their main function is to suppress T cells. While evaluating T reg cells, we identified a population of Foxp3-positive cells that were CD11b(+)F4/80(+)CD68(+), indicating macrophage origin. These cells were observed in spleen, lymph nodes, bone marrow, thymus, liver, and other tissues of naive animals. To characterize this subpopulation of macrophages, we devised… CONTINUE READING
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