Foxp3 in control of the regulatory T cell lineage

@article{Zheng2007Foxp3IC,
  title={Foxp3 in control of the regulatory T cell lineage},
  author={Ye Zheng and Alexander Y Rudensky},
  journal={Nature Immunology},
  year={2007},
  volume={8},
  pages={457-462}
}
Foxp3, an X chromosome–encoded forkhead transcription factor family member, is indispensable for the differentiation of regulatory T cells. These cells have a vital role in preventing autoimmunity and pathology inflicted by uncontrolled immune responses to infections. Deficiency or mutation in Foxp3 in humans and mice leads to an early onset, highly aggressive and fatal autoimmune disease affecting various tissues. Here, we review recent advances in our understanding of the Foxp3-dependent… CONTINUE READING
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