Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis.

@article{Sugimoto2006Foxp3dependentA,
  title={Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis.},
  author={Naoshi Sugimoto and Takatoku Oida and Keiji Hirota and Kyoko Nakamura and Takashi Nomura and Takashi Uchiyama and Shimon Sakaguchi},
  journal={International immunology},
  year={2006},
  volume={18 8},
  pages={1197-209}
}
Naturally occurring CD25(+)CD4(+) regulatory T cells (Tregs) actively engage in the maintenance of immunologic self-tolerance and immunoregulation. They specifically express the transcription factor Forkhead box P3 (Foxp3) as a master control molecule for their development and function. Although several cell-surface molecules have been reported as Treg-specific markers, such as CD25, glucocorticoid-induced TNFR family-related gene/protein and CTL-associated molecule-4, they are also expressed… CONTINUE READING

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