Foxp3-deficient regulatory T cells do not revert into conventional effector CD4+ T cells but constitute a unique cell subset.

@article{Kuczma2009Foxp3deficientRT,
  title={Foxp3-deficient regulatory T cells do not revert into conventional effector CD4+ T cells but constitute a unique cell subset.},
  author={Michal P. Kuczma and Robert Podolsky and Nikhil Garge and Danielle Daniely and Rafal Pacholczyk and Leszek Ignatowicz and Piotr Kraj},
  journal={Journal of immunology},
  year={2009},
  volume={183 6},
  pages={3731-41}
}
Homeostasis in the immune system is maintained by specialized regulatory CD4(+) T cells (T(reg)) expressing transcription factor Foxp3. According to the current paradigm, high-affinity interactions between TCRs and class II MHC-peptide complexes in thymus "instruct" developing thymocytes to up-regulate Foxp3 and become T(reg) cells. However, the loss or down-regulation of Foxp3 does not disrupt the development of T(reg) cells but abrogates their suppressor function. In this study, we show that… CONTINUE READING

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