Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

@article{Gerriets2016Foxp3AT,
  title={Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression},
  author={Valerie A Gerriets and Rigel J Kishton and Marc O Johnson and Sivan Cohen and Peter J Siska and Amanda G. Nichols and Marc Warmoes and Aguirre A de Cubas and Nancie J MacIver and Jason W. Locasale and Laurence A Turka and Andrew D. Wells and Jeffrey C. Rathmell},
  journal={Nature Immunology},
  year={2016},
  volume={17},
  pages={1459-1466}
}
CD4+ effector T cells (Teff cells) and regulatory T cells (Treg cells) undergo metabolic reprogramming to support proliferation and immunological function. Although signaling via the lipid kinase PI(3)K (phosphatidylinositol-3-OH kinase), the serine-threonine kinase Akt and the metabolic checkpoint kinase complex mTORC1 induces both expression of the glucose transporter Glut1 and aerobic glycolysis for Teff cell proliferation and inflammatory function, the mechanisms that regulate Treg cell… CONTINUE READING
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