Foxp3⁺ Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production.

@article{OConnor2012Foxp3TC,
  title={Foxp3⁺ Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production.},
  author={Richard A. O'Connor and Stefan Floess and Jochen Huehn and Simon A Jones and Stephen Mark Anderton},
  journal={European journal of immunology},
  year={2012},
  volume={42 5},
  pages={1174-9}
}
Foxp3(+) T regulatory (Treg) cells can be induced to produce interleukin (IL)-17 by in vitro exposure to proinflammatory cytokines, drawing into question their functional stability at sites of inflammation. Unlike their splenic counterparts, Treg cells from the inflamed central nervous system (CNS-Treg cells) during EAE resisted conversion to IL-17 production when exposed to IL-6. We show that the highly activated phenotype of CNS-Treg cells includes elevated expression of the Th1-associated… CONTINUE READING