Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation.

@article{Weirather2014Foxp3CT,
  title={Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation.},
  author={Johannes Weirather and Ulrich Dipl.-Phys. Hofmann and Niklas Beyersdorf and Gustavo Campos Ramos and Benjamin Vogel and Anna Barbara Frey and Georg Ertl and Thomas Kerkau and Stefan Frantz},
  journal={Circulation research},
  year={2014},
  volume={115 1},
  pages={
          55-67
        }
}
RATIONALE An exaggerated or persistent inflammatory activation after myocardial infarction (MI) leads to maladaptive healing and subsequent remodeling of the left ventricle. Foxp3(+) CD4(+) regulatory T cells (Treg cells) contribute to inflammation resolution. Therefore, Treg cells might influence cardiac healing post-MI. OBJECTIVE Our aim was to study the functional role of Treg cells in wound healing post-MI in a mouse model of permanent left coronary artery ligation. METHODS AND RESULTS… CONTINUE READING

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