Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease.

@article{Sakaguchi2006Foxp3CC,
  title={Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease.},
  author={Shimon Sakaguchi and Masahiro Ono and Ruka Setoguchi and Haruhiko Yagi and Shohei Hori and Zolt{\'a}n Feh{\'e}rv{\'a}ri and Jun Shimizu and Takeshi Takahashi and Takashi Nomura},
  journal={Immunological reviews},
  year={2006},
  volume={212},
  pages={
          8-27
        }
}
Naturally arising CD25+ CD4+ regulatory T (Treg) cells, most of which are produced by the normal thymus as a functionally mature T-cell subpopulation, play key roles in the maintenance of immunologic self-tolerance and negative control of a variety of physiological and pathological immune responses. Natural Tregs specifically express Foxp3, a transcription factor that plays a critical role in their development and function. Complete depletion of Foxp3-expressing natural Tregs, whether they are… CONTINUE READING

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