Foxp2 and Foxp1 cooperatively regulate lung and esophagus development.

  title={Foxp2 and Foxp1 cooperatively regulate lung and esophagus development.},
  author={Weiguo Shu and Min Min Lu and Yuzhen Zhang and Philip W. Tucker and Deying Zhou and Edward E Morrisey},
  volume={134 10},
The airways of the lung develop through a reiterative process of branching morphogenesis that gives rise to the intricate and extensive surface area required for postnatal respiration. The forkhead transcription factors Foxp2 and Foxp1 are expressed in multiple foregut-derived tissues including the lung and intestine. In this report, we show that loss of Foxp2 in mouse leads to defective postnatal lung alveolarization, contributing to postnatal lethality. Using in vitro and in vivo assays, we… CONTINUE READING
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