Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18.

@article{Leishman2013Foxp1MH,
  title={Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18.},
  author={Erin Leishman and Jeffrey M. Howard and Gloria E Queipo Garc{\'i}a and Qi Miao and Amy Tsu Ku and Joseph D Dekker and Haley W Tucker and Hoang K. Nguyen},
  journal={Development},
  year={2013},
  volume={140 18},
  pages={3809-18}
}
Hair follicles cyclically degenerate and regenerate throughout adult life and require regular stem cell activation to drive the cycle. In the resting phase of the hair cycle, hair follicle stem cells are maintained in a quiescent state until they receive signals to proliferate. We found that the forkhead transcription factor Foxp1 is crucial for maintaining the quiescence of hair follicle stem cells. Loss of Foxp1 in skin epithelial cells leads to precocious stem cell activation, resulting in… CONTINUE READING