Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.

@article{Feng2010Foxp1IA,
  title={Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.},
  author={Xiaoming Feng and Gregory C Ippolito and Lifeng Tian and Karla R. Wiehagen and Soyoung Oh and Arivazhagan Sambandam and Jessica Willen and Ralph Milford Bunte and Shanna D. Maika and June V. Harriss and Andrew J. Caton and Avinash Bhandoola and Philip W. Tucker and Hui Hu},
  journal={Blood},
  year={2010},
  volume={115 3},
  pages={510-8}
}
Proper thymocyte development is required to establish T-cell central tolerance and to generate naive T cells, both of which are essential for T-cell homeostasis and a functional immune system. Here we demonstrate that the loss of transcription factor Foxp1 results in the abnormal development of T cells. Instead of generating naive T cells, Foxp1-deficient single-positive thymocytes acquire an activated phenotype prematurely in the thymus and lead to the generation of peripheral CD4(+) T and CD8… CONTINUE READING
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